Synergistic apoptosis following endoplasmic reticulum stress aggravation in mucinous colon cancer
Abstract Background Mucinous colon cancers (MCC) are characterized by abundant production of mucin Warranty 2 (MUC2) protein and are less sensitive to standard systemic chemotherapy.We postulated that severe/persistent endoplasmic reticulum stress (ERS) aggravation in MCC would overwhelm compensatory cytoprotective pathways and induce apoptosis.Res